Gunslinger Girl has been released as a series both on DVD and in Book format. I enjoyed it so much I have both!
The story is set in Italy and follows The Social Welfare Agency, an organisation which takes little girls who will never recover from illness or injury and turns them into Cyborgs. They are then conditioned and trained to work with a handler as assassins.
Throughout the series new Cyborgs are introduced and their stories are developed, in the Finale we finally see Claes come in to her own as she fights to save her garden. Claes is a first generation Cyborg and can no longer fight due to memory loss, so she spends her time in the garden or studying.
This has to be my favourite of all the Manga books I’ve read. You can find them all on Amazon or, if you have one local, a bookshop.